Synthesis of DNA oligonucleotides in mesoporous silicon
نویسندگان
چکیده
منابع مشابه
Synthesis of mixed-sequence oligonucleotides on mesoporous silicon: chemical strategies and material stability
Rapid screening tests in medical diagnostic and environmental analysis are often based on oligonucleotide biochips. In this paper, we studied the stability of functionalized mesoporous silicon supports in the solid-phase synthesis of oligonucleotides, exploiting several chemical procedures. A 19-mer mixed sequence has been successfully synthesized on aminosilane-modified porous silicon photonic...
متن کاملSpecific Inhibition of the Expression of the Promyelocytic Leukemia (PML) Protein by Anti-Sense Oligonucleotides
In the present study, using anti-sense oligonucleotides the inhibition of expression of the PML protein hasbeen investigated. The anti-sense oligonucleotides were designed against the translation initiation site ofthe PML gene, and their effects were investigated on cellular growth and DNA synthesis. Incubation of normalhuman fibroblast cells with the anti-sense oligonucleotid...
متن کاملSynthesis of Three - Dimensional Mesoporous Silicon from Rice Husk via SHS Route
Silicon nanoparticles are the focus of attention thanks to their potentialities in advanced applications such as new batteries, photovoltaic cells and so on. The need to porous silicon is thus rising and will follow the same trend. In this work, highly porous nanostructured silicon is synthesized via Self-propagating high-temperature synthesis (SHS) route. Microstructural and phase analyses sho...
متن کاملSynthesis of mesoporous TiO2-SiO2-Ag and investigation of its structural and photocatalytic properties under visible light and ultra-violate
In this project, mesoporous titanium oxide-silicon oxide doped by silver (TiO2-SiO2-Ag) was hydrothermally synthesized. Titanium isopropoxide, tetraethyl orthosilicate and silver nitrate were used as precursors for TiO2, SiO2 and Ag, respectively. Initially TiO2-SiO2 mesoporous nanocomposite was synthesized with weight ratios of silica to titania SiO2:TiO2:3:1 via hydrothermal method at 70˚C an...
متن کاملAminosilane functionalizations of mesoporous oxidized silicon for oligonucleotide synthesis and detection.
Direct solid phase synthesis of peptides and oligonucleotides (ONs) requires high chemical stability of the support material. In this work, we have investigated the passivation ability of porous oxidized silicon multilayered structures by two aminosilane compounds, 3-aminopropyltriethoxysilane and 3-aminopropyldimethylethoxysilane (APDMES), for optical label-free ON biosensor fabrication. We ha...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2009